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Consistent with the effects in rat PSCs, high glucose and TGF1 levels enhanced the proliferation and decreased the apoptosis of PSCs in the LG group, whereas GSH and SB431542 prevented the effects induced by high glucose

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The in vitro environment exposes gametes and embryos to an excess of ROS with the absence of enzymatic antioxidant protection normally present during in vivo fertilization and pregnancy

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Molecular Characteristics Complete Specifications: CAS Registry Number: NOT ASSIGNED (synthetic modified peptide) Molecular Weight: 431.40 Da (42 Da higher than Epitalon due to acetyl group) Molecular Formula: CHNO Amino Acid Sequence: N-Ac-Ala-Glu-Asp-Gly (acetylated AEDG) Modification: N-terminal acetylation (acetyl group: COCH) Peptide Classification: Synthetic modified tetrapeptide Appearance: White to off-white lyophilized powder Solubility: Water, bacteriostatic water, phosphate buffered saline The N-acetyl modification adds 42 Da to the molecular weight compared to unmodified Epitalon (390.35 Da)

This indicates that pSiNPs and their multifunctional strategies have strong potential for cancer treatment and gene delivery research